A unique, national RESOURCE...

that provides investigators throughout the United States access to cells, plasma or whole blood from normal subjects who can be selected based on genotype

The GAP Registry currently has over 6,000 normal subjects who are available to provide samples for research. Volunteers are characterized for genetic variants of interest and have provided basic medical history information, which allows selection of subjects/samples based on specific genotype criteria, and/or traditional criteria such as age or ethnic background. To learn more about data available on participants, click here.

The majority of subjects in the registry have been analyzed on the "Immunochip", a custom SNP chip that captures the top 200 regions involved in risk for autoimmunity. A subset of subjects has full GWAS data available, and investigators can request specific genotyping of interest for their studies.

The GAP makes it possible to conduct detailed functional studies in unaffected subjects who carry risk alleles or protective alleles for various diseases without the complications of disease activity and/or medication.

Investigators receive de-identified samples and generally do not require IRB approval, as they are not considered engaged in human subject research.

The application process is easy and straightforward. All that is required is a 1- 2 page proposal, describing your study rationale, experimental design and details of genotype selection criteria. All proposals will be reviewed by the GAP's oversight committee. After approval and completion of a Sample Use Agreement, samples can be accessed. There are nominal fees to cover cost of sample preparation and shipping.

The GAP Registry was initially funded by NIH grant RC2AR059092-01 awarded to Feinstein Institute for Medical Research Principal Investigators Peter K. Gregersen, MD and Betty Diamond, MD.

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